1. Which of the following antipsychotics is known to elevate serum prolactin levels?

A. Quetiapine

B. Clozapine

C. Aripiprazole

D. Amisulpride

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2. Which category of drugs are associated with neuroleptic malignant syndrome?

A. Antidepressants

B. Anticholinergics

C. Antipsychotics

D. Mood stabilizers

E. Anxiolytics

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3. Tetrabenazine is found to be effective in controlling:

A. Neuroleptic-induced parkinsonism

B. Neuroleptic-induced tardive dyskinesia

C. Weight gain

D. Hyperprolactemia

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4. Which neuroleptic agent has the lowest likelihood of producing tardive dyskinesia?

A. Imipramine

B. Chlorpromazine

C. Clozapine

D. Fluoxetine

E. Thiothixene

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5. Which drug may be useful in the management of the neuroleptic malignant syndrome, although it can worsen the symptoms of schizophrenia?

A. Risperidone

B. Thiothixene

C. Haloperidol

D. Bromocriptine

E. Valproic acid

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6. Antagonism of which dopaminergic pathway is atributed to be the cause of therapeutic actions of antipsychotic drugs?

A. Nigrostriatal system

B. Mesolimbic–mesocortical system

C. Tuberoinfundibular pathway

D. Reticular activating system

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7. A patient reports fever, sore throat, or cellulitis, after 2 weeks of starting antipsychotic therapy with clozapine. Which of the following intervention is most important?

A. Treat the patient with a broad-spectrum antibiotic and continue the therapy

B. Discontinue the antipsychotic and conduct WBC and differential counts.

C. Inform the patient that it is common to develop fever and sore throat when taking this drug

D. Hospitalize the patient for observation

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8. Which of the following is a phenothiazine?

A. Chlorpromazine

B. Clozapine

C. Olanzapine

D. Risperidone

E. Haloperidol

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9. Which of the following statements about side effects of antipsychotics (AP) is NOT correct?

A. APs produce menorrhea and increased libido in women

B. APs produce decreased libido and gynecomastia in men.

C. APs cause inhibition of prolactin secretion.

D. Low-potency APs cause orthostatic hypotension

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10. Which of the following mechanism is considered to be the cause of extrapyramidal reactions?

A. Alpha-adrenoceptor blockade

B. D2-receptor blockade

C. H1 histamine receptor blockade

D. D2-receptor up-regulation

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11. Which of the following agents possesses pharmacological actions characterized by high antipsychotic potency and high potential for extrapyramidal toxicity?

A. Thioridazine

B. Haloperidol

C. Flumazenil

D. Clozapine

E. Carbamazepine

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12. Tardive dyskinesia after long-term antipsychotic administration is thought to be due to

A. A decrease in dopamine synthesis

B. Enhanced stimulation of D2 dopamine autoreceptors

C. Loss of cholinergic neurons in striatum

D. Up-regulation of striatal dopamine receptors

E. Increased tolerance to antipsychotic agents

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13. What is the chlorpromazine (100 mg) equivalent oral dose of haloperidol?

A. 2 mg

B. 10 mg

C. 30 mg

D. 100 mg

E. 300 mg

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14. Which of the following manifestations is NOT caused by blockade of Muscarinic cholinoreceptor?

A. Dry mouth

B. Blurred vision

C. Urinary retention

D. Constipation

E. Amenorrhea

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15. Which of the following is a butyrophenone?

A. Pimozide

B. Haloperidol

C. Fluphenazine

D. Trifluoperazine

E. Prochlorperazine

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