1. Which antidepressant is contraindicated in a patient with seizure disorder?

A. Nefazodone

B. Fluoxetine

C. Venlafaxine

D. Mirtazapine

E. Bupropion

Answer Key

2. Which of the following antidepressants is most selective for inhibition of neuronal reuptake of serotonin?

A. Mirtazapine

B. Venlafaxine

C. Bupropion

D. Sertraline

E. Imipramine

Answer Key

3. Which of the following condition is associated with long-term use of lithium in mood disorders?

A. Hypothyroidism

B. Hyperprolactinemia

C. Hypoglycemia

D. Hypertension

E. Tardive dyskinesia

Answer Key

4. Which of the following antidepressants requires therapeutic blood monitoring for safe use?

A. Paroxetine

B. Phenelzine

C. Nortriptyline

D. Venlafaxine

E. Bupropion

Answer Key

5. Combining MAOIs with SSRIs may cause

A. Serotonin Syndrome

B. Extrapyramidal Symptoms (EPS)

C. Neroleptic Malignant Syndrome (NMS)

D. Agranulocytosis

Answer Key

6. Penile priapism is known to be associated with use of

A. Buproprion

B. Venlafaxine

C. Escitalopram

D. Trazadone

E. Mirtazapine

Answer Key

A. Bupropion

B. Mirtazapine

C. Citalopram

D. Paroxetine

Answer Key

8. Sedation associated with use of antidepressants is attributed to the

A. Blockade of histamine H1 receptor

B. Blockade of muscarinic acetylcholine receptors

C. Blockade of alpha-1-receptors

D. Antagonism of 5-HT2 receptors

Answer Key

9. Which is a clinician-rated scale for monitoring outcome of depression treatment?

A. Beck Depression Inventory (BDI)

B. Zung Depression Scale

C. Geriatric Depression Scale (GDS)

D. Hamilton Depression Rating Scale (HAM-D)

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10. Therapeutic options for refractory depression include all, EXCEPT:

A. Lithium Augmentation

B. Thyroid hormone supplementation

C. Stimulant augmentation

D. Transcranial magnetic stimulation

E. Glucocorticoid therapy

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11. Which of the following is NOT associated with use of Tricyclic Antidepressants (TCA)?

A. Dry mouth

B. Constipation

C. Blurred vision

D. Urinary Incontinance

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12. The recommended dose of duloxetine for major depressive disorder is

A. 40–60 mg/day

B. 75-150 mg/day

C. 300–600 mg/day

D. 37.5-75 mg/day

Answer Key

13. Which of the following is known to have least cardiovascular side effects?

A. Amitriptyline

B. Imipramine

C.Citalopram

D. Clomipramine

Answer Key

14. A common adverse effect of Venlafaxine is

A. Increase in blood pressure

B. Decrese in blood pressure

C. Hypersalivation

D. Bradycardia

E. Tinnitus

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15. Which of the following antidepressants has relatively short biological half-life?

A. Mirtazapine

B. Fluoxetine

C. Trazodone

D. Citalopram

E. Imipramine

Answer Key

16. Which of the following antidepressant is approved by FDA for Smoking cessation?

A. Fluvoxamine

B. Bupropion

C. Paroxetine

D. Venlafaxine

Answer Key

17. Which of the following is a RIMA—reversible inhibitor of monoamine oxidase group of antidepressant?

A. Phenelzine

B. Isocarboxazid

C. Tranylcypromine

D. Moclobemide

Answer Key

18. What is the best antidepressant prescribed for a patient with hypotension and cardiac disease?

A. Escitalopam

B. Duloxetine

C. Venlafaxine

D. Mirtazapine